from sys import exit from colour import * from rs.reaction_system import ReactionSystem class ReactionSystemWithConcentrations(ReactionSystem): def __init__(self): self.reactions = [] self.meta_reactions = dict() self.permanent_entities = dict() self.background_set = [] self.context_entities = [] # legacy. to be removed self.reactions_by_prod = None self.max_concentration = 0 self.max_conc_per_ent = dict() def add_bg_set_entity(self, e): name = "" def_max_conc = -1 if type(e) is tuple and len(e) == 2: name, def_max_conc = e elif type(e) is str: name = e print("\nWARNING: no maximal concentration level specified for:", e, "\n") else: raise RuntimeError("Bad entity type when adding background set element") self.assume_not_in_bgset(name) self.background_set.append(name) if def_max_conc != -1: ent_id = self.get_entity_id(name) self.max_conc_per_ent.setdefault(ent_id, 0) if self.max_conc_per_ent[ent_id] < def_max_conc: self.max_conc_per_ent[ent_id] = def_max_conc if self.max_concentration < def_max_conc: self.max_concentration = def_max_conc def get_max_concentration_level(self, e): if e in self.max_conc_per_ent: return self.max_conc_per_ent[e] else: return self.max_concentration def is_valid_entity_with_concentration(self, e): """Sanity check for entities with concentration""" if type(e) is tuple: if len(e) == 2 and type(e[1]) is int: return True if type(e) is list: if len(e) == 2 and type(e[1]) is int: return True print("FATAL. Invalid entity+concentration: {:s}".format(e)) exit(1) return False def get_state_ids(self, state): """Returns entities of the given state without levels""" return [e for e, c in state] def has_non_zero_concentration(self, elem): if elem[1] < 1: raise RuntimeError("Unexpected concentration level in state: " + str(elem)) def process_rip(self, R, I, P, ignore_empty_R=False): """Chcecks concentration levels and converts entities names into their ids""" if R == [] and not ignore_empty_R: raise RuntimeError("No reactants defined") reactants = [] for r in R: self.is_valid_entity_with_concentration(r) self.has_non_zero_concentration(r) entity, level = r reactants.append((self.get_entity_id(entity), level)) if self.max_concentration < level: self.max_concentration = level inhibitors = [] for i in I: self.is_valid_entity_with_concentration(i) self.has_non_zero_concentration(i) entity, level = i inhibitors.append((self.get_entity_id(entity), level)) if self.max_concentration < level: self.max_concentration = level products = [] for p in P: self.is_valid_entity_with_concentration(p) self.has_non_zero_concentration(p) entity, level = p products.append((self.get_entity_id(entity), level)) return reactants, inhibitors, products def add_reaction(self, R, I, P): """Adds a reaction""" if P == []: raise RuntimeError("No products defined") reaction = self.process_rip(R, I, P) self.reactions.append(reaction) def add_reaction_without_reactants(self, R, I, P): """Adds a reaction""" if P == []: raise RuntimeError("No products defined") reaction = self.process_rip(R, I, P, ignore_empty_R=True) self.reactions.append(reaction) def add_reaction_inc(self, incr_entity, incrementer, R, I): """Adds a macro/meta reaction for increasing the value of incr_entity""" reactants, inhibitors, products = self.process_rip( R, I, [], ignore_empty_R=True ) incr_entity_id = self.get_entity_id(incr_entity) self.meta_reactions.setdefault(incr_entity_id, []) self.meta_reactions[incr_entity_id].append( ("inc", self.get_entity_id(incrementer), reactants, inhibitors) ) def add_reaction_dec(self, decr_entity, decrementer, R, I): """Adds a macro/meta reaction for decreasing the value of incr_entity""" reactants, inhibitors, products = self.process_rip( R, I, [], ignore_empty_R=True ) decr_entity_id = self.get_entity_id(decr_entity) self.meta_reactions.setdefault(decr_entity_id, []) self.meta_reactions[decr_entity_id].append( ("dec", self.get_entity_id(decrementer), reactants, inhibitors) ) def add_permanency(self, ent, I): """Sets entity to be permanent unless it is inhibited""" ent_id = self.get_entity_id(ent) if ent_id in self.permanent_entities: raise RuntimeError("Permanency for {0} already defined.".format(ent)) inhibitors = self.process_rip([], I, [], ignore_empty_R=True)[1] self.permanent_entities[ent_id] = inhibitors def set_context_entities(self, entities): raise NotImplementedError def entities_names_set_to_str(self, entities): s = "" for entity in entities: s += entity + ", " s = s[:-2] return s def entities_ids_set_to_str(self, entities): s = "" for entity in entities: s += self.get_entity_name(entity) + ", " s = s[:-2] return s def state_to_str(self, state): s = "" for ent, level in state: s += self.get_entity_name(ent) + "=" + str(level) + ", " s = s[:-2] return s def show_background_set(self): print( C_MARK_INFO + " Background set: {" + self.entities_names_set_to_str(self.background_set) + "}" ) def show_meta_reactions(self): print(C_MARK_INFO + " Meta reactions:") for param_ent, reactions in self.meta_reactions.items(): for r_type, command, reactants, inhibitors in reactions: if r_type == "inc" or r_type == "dec": print( " - [ Type=" + repr(r_type) + " Operand=( " + self.get_entity_name(param_ent) + " ) Command=( " + self.get_entity_name(command) + " ) ] -- ( R={" + self.state_to_str(reactants) + "}, I={" + self.state_to_str(inhibitors) + "} )" ) else: raise RuntimeError("Unknown meta-reaction type: " + repr(r_type)) def show_max_concentrations(self): print( C_MARK_INFO + " Maximal allowed concentration levels (for optimized translation to RS):" ) for e, max_conc in self.max_conc_per_ent.items(): print(" - {0:^20} = {1:<6}".format(self.get_entity_name(e), max_conc)) def show_permanent_entities(self): print(C_MARK_INFO + " Permanent entities:") for e, inhibitors in self.permanent_entities.items(): print( " - {0:^20}{1:<6}".format( self.get_entity_name(e) + ": ", "I={" + self.state_to_str(inhibitors) + "}", ) ) def show(self, soft=False): self.show_background_set() self.show_reactions(soft) self.show_permanent_entities() self.show_meta_reactions() self.show_max_concentrations() def get_reactions_by_product(self): """Sorts reactions by their products and returns a dictionary of products""" if self.reactions_by_prod != None: return self.reactions_by_prod producible_entities = set() for reaction in self.reactions: product_entities = [e for e, c in reaction[2]] producible_entities = producible_entities.union(set(product_entities)) reactions_by_prod = {} for p_e in producible_entities: reactions_by_prod[p_e] = [] rcts_for_p_e = reactions_by_prod[p_e] for r in self.reactions: product_entities = [e for e, c in r[2]] if p_e in product_entities: reactants = r[0] inhibitors = r[1] products = [(e, c) for e, c in r[2] if e == p_e] prod_conc = products[0][1] insert_place = None # we need to order the reactions w.r.t. the concentration levels produced (increasing order) for i in range(0, len(rcts_for_p_e)): checked_conc = rcts_for_p_e[i][2][0][1] if prod_conc <= checked_conc: insert_place = i break if ( insert_place == None ): # empty or the is only one element which is smaller than the element being added # we append (to the end) rcts_for_p_e.append((reactants, inhibitors, products)) else: rcts_for_p_e.insert( insert_place, (reactants, inhibitors, products) ) # save in cache self.reactions_by_prod = reactions_by_prod return reactions_by_prod def get_reaction_system(self): rs = ReactionSystem() for reactants, inhibitors, products in self.reactions: new_reactants = [] new_inhibitors = [] new_products = [] for ent, conc in reactants: n = self.get_entity_name(ent) + "#" + str(conc) rs.ensure_bg_set_entity(n) new_reactants.append(n) for ent, conc in inhibitors: n = self.get_entity_name(ent) + "#" + str(conc) rs.ensure_bg_set_entity(n) new_inhibitors.append(n) for ent, conc in products: for i in range(1, conc + 1): n = self.get_entity_name(ent) + "#" + str(i) rs.ensure_bg_set_entity(n) new_products.append(n) rs.add_reaction(new_reactants, new_inhibitors, new_products) for param_ent, reactions in self.meta_reactions.items(): for r_type, command, reactants, inhibitors in reactions: param_ent_name = self.get_entity_name(param_ent) new_reactants = [] new_inhibitors = [] for ent, conc in reactants: n = self.get_entity_name(ent) + "#" + str(conc) rs.ensure_bg_set_entity(n) new_reactants.append(n) for ent, conc in inhibitors: n = self.get_entity_name(ent) + "#" + str(conc) rs.ensure_bg_set_entity(n) new_inhibitors.append(n) max_cmd_c = self.max_concentration if command in self.max_conc_per_ent: max_cmd_c = self.max_conc_per_ent[command] else: print( "WARNING:\n\tThere is no maximal concentration level defined for " + self.get_entity_name(command) ) print("\tThis is a very bad idea -- expect degraded performance\n") for l in range(1, max_cmd_c + 1): cmd_ent = self.get_entity_name(command) + "#" + str(l) rs.ensure_bg_set_entity(cmd_ent) if r_type == "inc": # pre_conc -- predecessor concentration # succ_conc -- successor concentration concentration for i in range(1, self.max_concentration): pre_conc = param_ent_name + "#" + str(i) rs.ensure_bg_set_entity(pre_conc) new_products = [] succ_value = i + l for j in range(1, succ_value + 1): if j > self.max_concentration: break new_p = param_ent_name + "#" + str(j) rs.ensure_bg_set_entity(new_p) new_products.append(new_p) if new_products != []: rs.add_reaction( set(new_reactants + [pre_conc, cmd_ent]), set(new_inhibitors), set(new_products), ) elif r_type == "dec": for i in range(1, self.max_concentration + 1): pre_conc = param_ent_name + "#" + str(i) rs.ensure_bg_set_entity(pre_conc) new_products = [] succ_value = i - l for j in range(1, succ_value + 1): if j > self.max_concentration: break new_p = param_ent_name + "#" + str(j) rs.ensure_bg_set_entity(new_p) new_products.append(new_p) if new_products != []: rs.add_reaction( set(new_reactants + [pre_conc, cmd_ent]), set(new_inhibitors), set(new_products), ) else: raise RuntimeError( "Unknown meta-reaction type: " + repr(r_type) ) for ent, inhibitors in self.permanent_entities.items(): max_c = self.max_concentration if ent in self.max_conc_per_ent: max_c = self.max_conc_per_ent[ent] else: print( "WARNING:\n\tThere is no maximal concentration level defined for " + self.get_entity_name(ent) ) print("\tThis is a very bad idea -- expect degraded performance\n") def e_value(i): return self.get_entity_name(ent) + "#" + str(i) for value in range(1, max_c + 1): new_reactants = [] new_inhibitors = [] new_products = [] new_reactants = [e_value(value)] for e_inh, conc in inhibitors: n = self.get_entity_name(e_inh) + "#" + str(conc) rs.ensure_bg_set_entity(n) new_inhibitors.append(n) for i in range(1, value + 1): new_products.append(e_value(i)) rs.add_reaction(new_reactants, new_inhibitors, new_products) return rs class ReactionSystemWithAutomaton(object): def __init__(self, reaction_system, context_automaton): self.rs = reaction_system self.ca = context_automaton def show(self, soft=False): self.rs.show(soft) self.ca.show() def is_with_concentrations(self): if not isinstance(self.rs, ReactionSystemWithConcentrations): return False if not isinstance(self.ca, ContextAutomatonWithConcentrations): return False return True def sanity_check(self): pass def get_ordinary_reaction_system_with_automaton(self): if not self.is_with_concentrations(): raise RuntimeError("Not RS/CA with concentrations") ors = self.rs.get_reaction_system() oca = self.ca.get_automaton_with_flat_contexts(ors) return ReactionSystemWithAutomaton(ors, oca) # EOF