#!/usr/bin/env python # # Copyright (c) 2015-2019 Artur Meski # # Permission is hereby granted, free of charge, to any person obtaining a copy # of this software and associated documentation files (the "Software"), to deal # in the Software without restriction, including without limitation the rights # to use, copy, modify, merge, publish, distribute, sublicense, and/or sell # copies of the Software, and to permit persons to whom the Software is # furnished to do so, subject to the following conditions: # # The above copyright notice and this permission notice shall be included in all # copies or substantial portions of the Software. # # THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR # IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, # FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE # AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER # LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, # OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE # SOFTWARE. # from rs import * from smt import * import sys import resource def heat_shock_response(print_system=True, verify_rsc=True): if len(sys.argv) < 1+1: print("{source} ".format(source=sys.argv[0])) print("type:") print(" - 1 -- RSC") print(" - 0 -- RSC translated into RS") print() exit(1) verify_rsc=bool(int(sys.argv[1])) stress_temp = 42 max_temp = 50 r = ReactionSystemWithConcentrations() r.add_bg_set_entity(("hsp",1)) r.add_bg_set_entity(("hsf",1)) r.add_bg_set_entity(("hsf2",1)) r.add_bg_set_entity(("hsf3",1)) r.add_bg_set_entity(("hse",1)) r.add_bg_set_entity(("mfp",1)) r.add_bg_set_entity(("prot",1)) r.add_bg_set_entity(("hsf3:hse",1)) r.add_bg_set_entity(("hsp:mfp",1)) r.add_bg_set_entity(("hsp:hsf",1)) r.add_bg_set_entity(("temp",max_temp)) r.add_bg_set_entity(("heat",1)) r.add_bg_set_entity(("cool",1)) r.add_reaction([("hsf",1)], [("hsp",1)], [("hsf3",1)]) r.add_reaction([("hsf",1),("hsp",1),("mfp",1)], [], [("hsf3",1)]) r.add_reaction([("hsf3",1)], [("hse",1),("hsp",1)],[("hsf",1)]) r.add_reaction([("hsf3",1),("hsp",1),("mfp",1)], [("hse",1)], [("hsf",1)]) r.add_reaction([("hsf3",1),("hse",1)], [("hsp",1)], [("hsf3:hse",1)]) r.add_reaction([("hsp",1),("hsf3",1),("mfp",1),("hse",1)],[], [("hsf3:hse",1)]) r.add_reaction([("hse",1)], [("hsf3",1)], [("hse",1)]) r.add_reaction([("hsp",1),("hsf3",1),("hse",1)], [("mfp",1)], [("hse",1)]) r.add_reaction([("hsf3:hse",1)], [("hsp",1)], [("hsp",1),("hsf3:hse",1)]) r.add_reaction([("hsp",1),("mfp",1),("hsf3:hse",1)],[], [("hsp",1),("hsf3:hse",1)]) r.add_reaction([("hsf",1),("hsp",1)], [("mfp",1)], [("hsp:hsf",1)]) r.add_reaction([("hsp:hsf",1),("temp",stress_temp)],[], [("hsf",1),("hsp",1)]) r.add_reaction([("hsp:hsf",1)], [("temp",stress_temp)],[("hsp:hsf",1)]) r.add_reaction([("hsp",1),("hsf3:hse",1)], [("mfp",1)], [("hse",1),("hsp:hsf",1)]) r.add_reaction([("temp",stress_temp),("prot",1)], [], [("mfp",1),("prot",1)]) r.add_reaction([("prot",1)], [("temp",stress_temp)], [("prot",1)]) r.add_reaction([("hsp",1),("mfp",1)], [], [("hsp:mfp",1)]) r.add_reaction([("mfp",1)], [("hsp",1)], [("mfp",1)]) r.add_reaction([("hsp:mfp",1)], [], [("hsp",1),("prot",1)]) r.add_reaction_inc("temp", "heat", [("temp",1)],[("temp",max_temp)]) r.add_reaction_dec("temp", "cool", [("temp",1)],[]) r.add_permanency("temp",[("heat",1),("cool",1)]) c = ContextAutomatonWithConcentrations(r) c.add_init_state("0") c.add_state("1") c.add_transition("0", [("hsf",1),("prot",1),("hse",1),("temp",35)], "1") c.add_transition("1", [("cool",1)], "1") c.add_transition("1", [("heat",1)], "1") c.add_transition("1", [], "1") rc = ReactionSystemWithAutomaton(r,c) if print_system: rc.show() prop_req = [ ("mfp",1) ] prop_block = [ ] prop = (prop_req,prop_block) rs_prop = (state_translate_rsc2rs(prop_req),state_translate_rsc2rs(prop_block)) if verify_rsc: smt_rsc = SmtCheckerRSC(rc) smt_rsc.check_reachability(prop,max_level=40) else: orc = rc.get_ordinary_reaction_system_with_automaton() if print_system: print("\nTranslated:") orc.show() smt_tr_rs = SmtCheckerRS(orc) smt_tr_rs.check_reachability(rs_prop) def state_translate_rsc2rs(p): return [e[0] + "#" + str(e[1]) for e in p] def main(): heat_shock_response() if __name__ == "__main__": main() # EOF